The Establishment was made possible by the joint efforts of the City of Florence, the Foundation “Istituto degli Innocenti”, the International Centre “Birth and Culture” and the Meyer Children’s Hospital of Florence. The school was a permanent home in the prestigious medieval building of the “Ospedale degli Innocenti” which was the first Children’s Hospital built in Europe, by the master architect Brunelleschi. Nowadays, the building is in part a museum, a conference center and a meeting center. It is also the permanent home of the UNICEF research office in Europe. The “Istituto degli Innocenti” (Institutes of the Innocents) in Florence has been working for nearly six centuries on behalf of the family and the child. At the time when it was established, during the first half of the fifteenth century, it was the first institution in the known world devoted exclusively to child care. Still today, the Institute is accommodated at Piazza della Santissima Annunziata, in the building of the historical Hospital designed and built by Filippo Brunelleschi, which turned it into a wonderful example of Renaissance architecture. With the passing of time, it has kept on being enriched by the contribution of famous artists. The history of the Institute is immense and, in addition to its complex artistic and monumental heritage, it develops over an age-old experience in caring for children.